(IL-3) Stimulates the Clonal Growth of Pulmonary Alveolar Macrophage of the Mouse: Role of IL-3 in the Regulation of Macrophage Production Outside the Bone Marrow
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چکیده
lnterleukin-3 (11-3) is one of the hematopoietic growth factors that regulates the growth and differentiation of pluripotent stem cells, thereby leading to the production of all the major blood cell types. The role of 11-3 in the regulation of pulmonary alveolar macrophage (PAM) production was investigated. 11-3 stimulated the proliferation and clonal growth of murine PAM with a dose-response curve similar to that of bone marrow granulocyte-macrophage colony-forming cells. The 11-3-induced colony formation by cells outside the bone marrow appeared to be unique to PAM; 11-3 failed to cause colony formation by both peritoneal exudate macrophages (PEM) and blood monocytes. Unlike bone marrow stem cells, PAM are
منابع مشابه
Interleukin-3 (IL-3) stimulates the clonal growth of pulmonary alveolar macrophage of the mouse: role of IL-3 in the regulation of macrophage production outside the bone marrow.
Interleukin-3 (IL-3) is one of the hematopoietic growth factors that regulates the growth and differentiation of pluripotent stem cells, thereby leading to the production of all the major blood cell types. The role of IL-3 in the regulation of pulmonary alveolar macrophage (PAM) production was investigated. IL-3 stimulated the proliferation and clonal growth of murine PAM with a dose-response c...
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